vns86com威尼斯城

Æë³ҽѧ²¿ÈËÊ´¦
vns86com威尼斯城Ê×Ò³  |  ÉèΪÊ×Ò³  |  ¼ÓÈëÊղؠ

vns86com威尼斯城: ¶¯Ì¬ÐÅÏ¢

È˲Ŷ¯Ì¬
µ±Ç°Î»ÖÃ: ÍøÕ¾Ê×Ò³ >> È˲Ŷ¯Ì¬ >> ÕýÎÄ

    vns86com威尼斯城:¹«ÎÀѧԺѦ¸¶ÖÒ½ÌÊÚÍŶÓÇàÄê½ÌʦԬÖÐÉÐÔÚNature Communications·¢±íTWASͳ¼ÆÍƶÏз½·¨

    ¡¾·¢²¼Ê±¼ä£º2020-08-02 08:35:06 ä¯ÀÀ´ÎÊý£º ×÷ÕߣºÁõè´ À´×Ô£ºÉ½´óÊÓµã ÔðÈα༭£ºÍõÇïÉú¡¿

    7ÔÂ31ÈÕ£¬Nature CommunicationsÔÓÖ¾(IF=12.121)·¢±íÁËÌâΪ¡°Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies¡±µÄȫת¼×鹨Áª·ÖÎö£¨TWAS£©Í³¼ÆÍƶÏз½·¨£¬¹«ÎÀѧԺÉúÎïͳ¼ÆÏµÑ¦¸¶ÖÒ½ÌÊÚÍŶÓÇàÄê½ÌʦԬÖÐÉи±½ÌÊÚΪ¸ÃÂÛÎĵĵÚÒ»×÷Õߣ¬ÃÜЪ¸ù´óѧÉúÎïͳ¼ÆÏµXiang Zhou½ÌÊÚΪͨѶ×÷Õߣ¬vns86com威尼斯城ΪµÚÒ»Íê³Éµ¥Î»¡£

    ȫת¼×鹨ÁªÑо¿(TWAS)Ö¼ÔÚÕûºÏÈ«»ùÒò×鹨ÁªÑо¿(GWASs)ºÍ±í´ïÊýÁ¿ÐÔ×´»ùÒò×ù(eQTL)µÄ¹ØÁª½á¹û£¬ÒÔÆÚ½øÒ»²½²ûÃ÷¸´ÔÓ¼²²¡ÄÚÔÚ·Ö×ÓÒÅ´«»úÖÆ¡£TWASËä¾ßÓÐÁ¼ºÃµÄÉúÎïҽѧ»ù´¡£¬µ«µ±Ç°Í³¼Æ·ÖÎö·½·¨´æÔÚÖÚ¶àȱÏÝ¡£¸ÃÑо¿´ÓÃϵ¶ûËæ»ú»¯£¨MR£©µÄ½Ç¶ÈÖØÐÂÉóÊÓÏÖÓеÄTWAS·ÖÎö·½·¨£¬Ìá³öTWAS·ÖÎö¿ÉÒÔ¿´³ÉÁ½²ãÃæ×éѧÊý¾ÝµÄÕûºÏÎÊÌ⣬Æä·ÖÎö¶¼¿ÉÒÔͳһµ½MR¿ò¼ÜÄÚ£¬²¢ÔÚ´Ë»ù´¡ÉÏÌá³öÁËÄܹ»Í¬Ê±¿ØÖÆSNP¼äLD¹ØÏµÒÔ¼°Ë®Æ½¶àЧÐÔ£¨Horizontal pleiotropy£©µÄPMR-Egger·½·¨¡£PMR-Egger¿¼ÂÇÁ˶à¸öÏà¹Ø¹¤¾ß±äÁ¿£¬ÊµÏÖÁËÔÚˮƽ¶àЧÐÔ´æÔÚµÄÌõ¼þÏ£¬¼ìÑé»ùÒò±í´ï£¨gene expression£©¶ÔÐÔ×´µÄÒò¹ûЧӦ¡£PMR-EggerÒÀÍÐÁªºÏËÆÈ»ÀíÂÛ¿ò¼Ü£¬´óÁ¿µÄͳ¼ÆÄ£Äâ֤ʵÁËÏà±È´«Í³µÄTWAS·ÖÎö·½·¨£¬PMR-Egger¾ßÓÐÁ¼ºÃµÄͳ¼ÆÑ§Ð§ÄÜ¡£Í¬Ê±£¬PMR-Egger»¹¿ÉÒÔÖ±½Ó¼ìÑéÉúÎïѧÖй㷺´æÔÚµÄˮƽ¶àЧÐÔ¡£¸ÃÑо¿»¹½«PMR-Egger·½·¨Ó¦ÓÃÓÚ°üÀ¨Ó¢¹úÉúÎïÒøÐÐÊý¾Ý¿â(UK Biobank)ÔÚÄÚµÄÈý¸öGWASs¹²39ÖÖ¼²²¡ºÍ¸´ÔÓÐÔ×´µÄTWAS·ÖÎö£¬Ö¤ÊµÆäʵÓÃÐÔ¡£×îºó£¬¸ÃÑо¿½«PMR-Egger·½·¨·â×°³ÉR°ü£¬¹©Êµ¼ùÕßÓ¦Óá£Èí¼þ°üÁ´½ÓΪhttp://www.xzlab.org/software.html»òhttps://github.com/yuanzhongshang/PMR

    ´Ó2018Ä꿪ʼ£¬ÉúÎïͳ¼ÆÏµÑ¦¸¶ÖÒ½ÌÊÚÍŶÓÒ»Ö±±£³ÖºÍÃÜЪ¸ù´óѧXiang Zhou½ÌÊÚ¿ÎÌâ×éÔÚͳ¼ÆÒÅ´«Ñ§ÀíÂÛ·½·¨·½ÃæµÄºÏ×÷£¬ÏȺó̽Ë÷ÁËÄêÇá½Ìʦ»¥·Ã£¬Ñо¿ÉúÁªºÏÅàÑøµÈ¶àÖÖºÏ×÷ģʽ£¬¸ÃÑо¿³É¹ûµÄ·¢±í½«½øÒ»²½Íƶ¯Ë«·½µÄºÏ×÷ÔÙÉÏÐĄ̂½×¡£±¾Ñо¿µÚÒ»×÷ÕßÔ¬ÖÐÉи±½ÌÊÚÊÇѦ¸¶ÖÒÍŶӹǸɳÉÔ±£¬²©Ê¿Éúµ¼Ê¦£¬µÚ¶þÅúɽ¶«ÇàÄêѧÕßδÀ´¼Æ»®ÈëÑ¡Õߣ¬³¤ÆÚ´ÓÊÂ×éѧÓëϵͳÁ÷Ðв¡Ñ§Í³¼ÆÀíÂÛ·½·¨Ñо¿£¬³É¹ûÏȺ󷢱íÔÚNature Communications, Statistics in Medicine, Human Molecular Genetics, GeneticsµÈÔÓÖ¾¡£

    ¸ÃÑо¿µÃµ½ÁËÃÀ¹úNIH»ù½ð(R01HG009124, R01HL142023)£¬NSF»ù½ð(DMS1712933)£¬ÒÔ¼°¹ú¼Ò×ÔÈ»»ù½ðÃæÉÏÏîÄ¿(81872712, 81673272)£¬É½¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðÖØ´ó»ù´¡Ñо¿ÏîÄ¿(ZR2019ZD02)£¬vns86com威尼斯城ÇàÄêѧÕßδÀ´¼Æ»®(2016WLJH23)µÈ×ÊÖú¡£

    Ô­ÎÄÁ´½Ó£ºTesting and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies

    ÉÏÒ»Ìõ£º»¤ÀíѧԺÍõ¿Ë·¼½ÌÊÚµ±Ñ¡ÃÀ¹ú»¤Àí¿ÆÑ§ÔºÔºÊ¿
    ÏÂÒ»Ìõ£ºÖйú¿ÆÑ§ÔºÔºÊ¿ÕÔ¹úÆÁÊÜÆ¸vns86com威尼斯城˫ƸԺʿ

    ¡¾¹Ø±Õ¡¿

°æÈ¨ËùÓУºvns86com威尼斯城    µØÖ·£ºÉ½¶«Ê¡¼ÃÄÏÊÐÀúÏÂÇøÎÄ»¯Î÷·44ºÅ   
Óʱࣺ250012    ÁªÏµµç»°£º0531-88380106   ÓÊÏ䣺yxbzzh@sdu.edu.cn

ÍøÕ¾¹ÜÀíµÇ½

vns86com威尼斯城-9778818威尼斯官网